I Ricercatori


Prof. Pietro Calissano
Meccanismi Molecolari di Neurodegenerazione

Group Leader

Tags:

Educazione e prime posizioni

Present position:

Director, Institute of Neurobiology and Molecular Medicine, CNR, Rome Full Professor of Neurophysiology, Università Tor Vergata, Roma Vice-President, European Brain Research Institute (EBRI) founded by Rita Levi Montalcini

Short Cursus honorum

Born in Genova, January 30, 1938

1964 Degree in Medicine magna cum laude

1965 Research position at the Center of Neurobiology, CNR directed by R.Levi Montalcini

1966-67 Research Associate at the Dept. of Biology, Washington University of St. Louis, MO USA 1967-68 Acting Laboratory Director at the same University

1970-71 EMBO Fellowship at the Institute of Animal Physiology, Cambridge, UK 1971 PhD in Biochemistry, University of Roma

1973 Research Director at the Laboratory of Cell Biology, CNR, EMBO Fellowship at the Dept. of Neurobiology of the Weizmann Institute, Israel

1977-78 Visiting Professor at the Dept. of Neuropathology, Children´s Hospital Medical Center, Harvard Medical School.

1978 Member of European Molecular Biology Organization (EMBO)

1986 - present Full Professor in Neurophysiology, II University of Rome

1988 Director of the Institute of Neurobiology, CNR, Rome

1995 - present Member of the Scientific Council of the Istituto della Enciclopedia Treccani, Roma

1996 - present Member of the Italian Academy of Sciences

2000 - present Director of the Institute of Neurobiology and Molecular Medicine, CNR, Rome

2002 - present Vice-president of the European Brain Research Institute

Experimental work and participation to international meetings as invited speaker. Calissano has published 135 scientific papers in international scientific journals, has attended 65 international meetings as an invited speaker and communicated his scientific experimental work at numerous seminars in different Italian and foreign universities.

Scientific divulgation

Calissano has published 30 articles of divulgation in different italian newspapers and written two books entitled:

- Neuroni, mente ed evoluzione, Garzanti Editor (neurons, mind and evolution)
- Mente e cervello, Il Melangolo Editor (the mind/brain problem)

He has acted as scientific director and expert in biomedicine for 5 distinct Encyclopedias edited by the Treccani Institute:

- Frontiers of Life - Encyclopedia of Science and Technology
- Piccola Treccani Encyclopedia
- Sixth volume of the Grande Encyclopedia
- The encycopedia of the third millenium

Scientific Associations:

- European Molecular Biology Organization (EMBO),
- Italian Academy of Sciences - Italian Neuroscience Association
- Scientific Council of the Istituto dell´Enciclopedia Italiana Treccani Prizes and awards.
- Feltrinelli prize
- Prize awarded by the Italian Academy of Sciences.
- Neuburgh prize


Pubblicazioni

1. D´Mello S., Galli C., Ciotti M.T. and Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc.Natl.Acad.Sci., USA, 90: 10989-10993 (1993)

2. Canu N., Dus L., Barbato C., Ciotti M.T., Brancolini C., Rinaldi A.M., Novak M., Cattaneo A., Bradbury A., and Calissano P. (1998) Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J. Neurosci. 18: 7061-7074

3. Galli C., Piccini A., Ciotti M.T., Castellani L., Calissano P., Zaccheo D. and Tabaton M. (1998) Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis. P.N.A.S. USA, 95:1247-1252

4. Canu N., Barbato C., Ciotti M.T., Serafino A., Dus L. and Calissano P. (2000) Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. J. Neurosci., 20: 589-599

5. Canu,N. and Calissano P. (2003) In vitro cultred neurons for molecular studies correlating apoptosis with events related to Alzheimer disease. The Cerebellum Taylor and Francis edt. 2, 1-10

6. Atlante,A. Bobba,A. Calissano P. Passarella, S: and Mara,E. (2003) The apoptosis/necrosis transition in cerebellar granule cells depends on the mutual relationship of the antioxidant and the proteolytic systems which regulate ROS production and cytochrome c release en route to death. J.Neurochemistry 84, 960-971

7. Amadoro G., Serafino AL, Barbato C., Ciotti MT, Sacco A., Calissano P. and Canu,N. (2003) Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons. Cell Death and Differentiation(2004) 11,217-230

8. Bobba A., Atlante A., Azzariti A., Asgaramella G., Calissano P. and Marra E. (2004) Mitpchondrial impairment induced excytotoxic death in cerebellar granule cells Int. J. Mol. Med. 13,873-876

9. Barbato,C. Canu,N. Zambrano,N. Serafino,A. Minopoli G. Ciotti,M.T. Amadoro,G. Russo,T. and Calissano P. (2005) Interaction of tau with Fe65 links tau to APP. Neurobiology of Disease, 18, 399-408

10. S.Cavallaro and P.Calissano (2006) A genomic approach to investigate neuronal apoptosis Current Alzheimer research 3, 4-23

11. Matrone Ca, Di Luzio Aa, Meli Gb, D’Aguanno Sc,d, Severini Ca, Ciotti MTa, Cattaneo Ab,e and Calissano P (2008) 81-96. activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells(2007) J.Alzheimer.s Disease 13, 81-96


Premi


Collaborazioni Scientifiche


Componenti del gruppo

Giuseppina Amadoro, Carmela Matrone, Cinzia Severini, Stefania Ciafrè, Claudia Provenzano, Maria Teresa Ciotti, Delio Mercanti, Anna Di Luzio

Laboratorio di meccanismi Molecolari di Neurodegenerazione

COMPONENTI DEL GRUPPO


Giuseppina Amadoro | Research Scientist

Carmela Matrone | Post-doctoral Fellow

Cinzia Severini | Research Staff

Stefania Ciafrè | Research Technologist

Claudia Provenzano | Post-doctoral Fellow

Maria Teresa Ciotti | Research Technician

Delio Mercanti | Research Staff

Anna Di Luzio | Research Technician