Dr. Hélène Marie
Molecular Mechanisms of Synaptic Plasticity

Group Leader

Tags: Memory, Alzheimer, Synaptic Plasticity, Electrophysiology, CREB, Hippocampus

Education and Experiences

B.Sc. Honors in Molecular Biology, University of Edinburgh, UK

Ph.D. Wellcome Trust 4-year, Ph.D. Programme in Neuroscience, University College London, UK

Post-Doctoral Fellow in Robert Malenka´s laboratory, Dept of Psychiatry and Behavioral Sciences, Stanford University, USA

Group Leader, European Brain Research Institute, Rome, Italy


Peng Y. , He S., Marie H., Zeng S., Ma J., Tan Z., Lee S.Y., Malenka R.C., Yu X. Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 2009 Jan 15;61(1):71-84.

Restivo L., Tafi E., Ammassari-Teule M., Marie H. Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory. Hippocampus 2008 Nov 11. [Epub ahead of print].

Dong Y., Green T., Saal D., Marie H., Neve R., Nestler E.J., Malenka R.C. CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci. 2006 Apr;9(4):475-7

Morishita W., Marie H. & Malenka R.C. Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat. Neurosci. 2005 Aug, 8(8): 1043-50.

Marie H., Morishita W., Calakos N. & Malenka R.C. Generation of Silent synapses by acute in vivo expression of active CaMKIV or CREB. Neuron 2005 March 3, 45(5):741-52.

Marie H., Pratt S.J., Betson M., Epple H., Kittler J.T., Meek L., Moss S.J., Troyanovsky S., Attwell D., Longmore G.D.& Braga V.M. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha Catenin. J. Biol. Chem. 2003 Jan 10;278(2):1220-1228.

Marie H., Billups D., Bedford F.K., Dumoulin A., Goyal R.K., Longmore G.D., Moss S.J. & Attwell D. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol.Cell. Neurosci. 2002 Feb;19(2):152-164.

Hamann M., Rossi D.J., Marie H. & Attwell D. Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur. J. Neurosci. 2002 Jan;15(2):308-314.

Parkinson D.B., Dong Z., Bunting H., Whitfield J., Meier C., Marie H., Mirsky R. & Jessen K.R. Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta mediated death to Schwann cell differentiation. J. Neurosci. 2001 Nov 1;21(21):8572-8585.

Kanungo J., Pratt S.J., Marie H. & Longmore G.D. Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol. Biol. Cell. 2000 Oct; 11(10):3299-3313

Marie H. & Attwell D. C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells. J. Physiol. 1999 Oct 15;520 Pt 2:393-7.


Marie H. & Malenka R.C. Acute in vivo expression of recombinant proteins in the rat rain using Sindbis virus. Chapter 12 of The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. CRC Press. (2006) In press.


Alzheimer’s Association 2008 New Investigator Research Grant (NIRG) recipient (USA)

National Alliance for Research on Schizophrenia & Depression (NARSAD) Young Investigator
Award, (USA)

Member of the European Neuroscience Institute Young Investigator Network

1st Class Honours in Molecular Biology, Edinburgh University 1996-2000 Wellcome Trust, Ph.D. scholarship

Wellcome Trust International Prize Travelling Research Fellowship

Scientific Collaborations

Prof. Brunello Tirrozzi
Dipartimento di Fisica

La Sapienza, Roma

Dr. Addolorata Marasco, Ph.D.
Dipartimento di Matematica e Applicazioni “R. Caccioppoli”,

Complesso Universitario di Monte S. Angelo,

Napoli, Italy

Dr Panayiota Poirazi
Institute of Molecular Biology and Biotechnology Foundation for Research and Technology,

Heraklion, Crete, Greece

Dr. Cecconi
Fondazione Santa Lucia,

Rome, Italy

Dr. Ammassari-Teule
Fondazione Santa Lucia/CNR Instituto di Neuroscienze

Rome, Italy

Group Members

Cristina Marchetti, Gry Houeland, Elisiana Tafi, Armando Romani, Concetta Lena, Leiron Ferrarese, Mogtaba Rostamyan, Maria-Angela Rubinacci, Marco Benevento

Cristina Marchetti,

Gry Houeland,

Elisiana Tafi, Research Technician

Armando Romani - Ph.D. Student

Concetta Lena, Undergraduate Student

Leiron Ferrarese, Undergraduate Student

Mogtaba Rostamyan - Undergraduate Student
Maria-Angela Rubinacci, Undergraduate Student
Marco Benevento, Undergraduate Student