ricerca (sml)The unifying overall scientific approach pursued at EBRI is to identify how the complex electrical activity of neuronal cortical circuits, responsible for well defined learning and memory tasks, is orchestrated, at a cellular and molecular level, by patterns of cell-type specific gene/protein expression.
EBRI´s strategy to reach its long term scientific objectives is to develop new technologies to study brain function, by linking the different hierarchical levels of the brain into one unified conceptual framework, from molecules to higher functions, in a systems biology approach. EBRI envisages to implement these objectives via a multidisciplinary approach whereby collaborating scientists with distinct backgrounds will utilize techniques of molecular and cell biology, genetics, biophysics, bioinformatics, genomics and proteomics, electrophysiology and nanotechnology, towards the common goals of:

  • understanding the molecular basis of neurodegenerative diseases of high social and medical impact, such as Alzheimer´s
  • exploring the role of Nerve Growth Factor (NGF) in neurodegenerative diseases and neuronal regeneration
  • implementing new therapeutic strategies for neurodegenerative diseases based upon these results
  • investigating how molecular events involved in synaptic plasticity lead to learning and memory, in well defined experimental systems
  • building effective learning and adaptive brain-machine interfaces